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KMID : 1145520220080020129
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Journal of Radiopharmaceuticals and Molecular Probes
2022 Volume.8 No. 2 p.129 ~ p.137
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Bombesin-based Radiopharmaceuticals for Imaging and Therapy of Cancers Expressing Gastrin-releasing Peptide Receptor
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Lim Hwi-Soo
Kang Choong-Mo
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Abstract
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Bombesin has a high binding affinity to gastrin-releasing peptide receptor (GRPR) and can be used as a targeting ligand in GRPR-related cancers. Because GRPR is overexpressed in prostate cancer, bombesin analogues have been investigated extensively for diagnosis and treatment of prostate cancer. In nuclear medicine, bombesin derivatives labeled with radiometals such as55/57Co, 64Cu, 68Ga, 99mTc, and 177Lu or radiohalogen such as 131I and 211At were developed as markers for early detection of tumors and theragnostic tool for cancer treatment. This review focuses on the introduction of bombesin-based radiopharmaceuticals that are studied in pre-clinical or clinical research.
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KEYWORD
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Bombesin, GRPR, Prostate cancer, Peptide-based radiopharmaceuticals
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